Document 0077
 DOCN  M9490077
 TI    Comparison of cDNAs encoding the gibbon ape leukaemia virus receptor
       from susceptible and non-susceptible murine cells.
 DT    9411
 AU    Wilson CA; Farrell KB; Eiden MV; Laboratory of Cell Biology, National
       Institute of Mental Health,; Bethesda, Maryland 20892.
 SO    J Gen Virol. 1994 Aug;75 ( Pt 8):1901-8. Unique Identifier : AIDSLINE
       MED/94321979
 AB    The gibbon ape leukaemia virus (GaLV) family of type C retroviruses
       consists of five closely related viral isolates, GaLV SF, GaLV SEATO,
       GaLV Br, GaLV H and simian sarcoma-associated virus. The cDNA encoding
       the human receptor for GaLV SEATO had previously been isolated. We now
       demonstrate that all of the above GaLVs can use the human form of the
       GaLV receptor to infect cells. All murine cells analysed to date have
       been found to be resistant to infection by GaLVs owing to the absence of
       a functional GaLV receptor. We have now identified a murine cell line
       which is unique in its susceptibility to GaLV infection. This cell line
       was established from a Japanese feral mouse, Mus musculus molossinus. We
       cloned and sequenced the cDNA for the receptor expressed in these cells
       and compared it to the cDNA for the GaLV receptor expressed in resistant
       murine cells such as NIH 3T3 (derived from M. m. musculus) and MDTF
       (derived from M. dunni tail fibroblasts). The crucial region for GaLV
       infection (the fourth extracellular domain) from the functional M. m.
       molossinus GaLV receptor is quite divergent from the same region of the
       M. m. musculus and M. dunni proteins, but similar to that of the
       functional human GaLV receptor. These results confirm the importance of
       the amino acids of this region in GaLV receptor function.
 DE    Amino Acid Sequence  Animal  Cloning, Molecular  Comparative Study
       Disease Susceptibility  Human  Leukemia Virus, Gibbon Ape/*GROWTH &
       DEVELOPMENT  Leukemia, Experimental/*IMMUNOLOGY  Mice  Molecular
       Sequence Data  Receptors, Virus/CLASSIFICATION/*GENETICS  Retroviridae
       Infections/*IMMUNOLOGY  Sequence Analysis, DNA  Sequence Homology, Amino
       Acid  Species Specificity  Viral Interference  3T3 Cells  JOURNAL
       ARTICLE

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